NanoKnife Procedure at UPNT: Precision Treatment for Localized Prostate Cancer

What Is the NanoKnife Procedure?

At Urology Partners of North Texas (UPNT), we offer the NanoKnife procedure as an advanced, minimally invasive option for treating prostate cancer. This cutting-edge technique uses irreversible electroporation (IRE)—a method that delivers precise electrical pulses to destroy cancer cells without damaging surrounding healthy tissue. Unlike surgery or radiation, NanoKnife offers a high level of precision, making it ideal for patients focused on preserving urinary and sexual function.

How NanoKnife Technology Works

NanoKnife technology works by creating tiny, irreversible pores in the membranes of cancer cells using electrical pulses. These pores cause the cancer cells to break down, while sparing critical structures such as nerves, blood vessels, and the urethra. Unlike thermal methods like cryotherapy or radiofrequency ablation, this non-thermal approach ensures minimal collateral damage.

Ideal Candidates for NanoKnife Treatment

NanoKnife is particularly well-suited for men who:

Have a Solitary Focus of Cancer: It’s ideal for patients whose cancer is confined to a single lesion or one side of the prostate.
Are Focused on Preserving Function: Men who prioritize maintaining erectile function and urinary continence benefit most from this precise approach.
Need Salvage Therapy After Radiation: NanoKnife is also used in cases of prostate cancer recurrence following radiation therapy, offering a minimally invasive alternative to more aggressive salvage procedures.

How the NanoKnife Procedure Works

Here’s what patients can expect during the NanoKnife process:

Pre-Procedure Imaging: MRI and ultrasound are used for accurate tumor mapping.
Electrode Placement: Under real-time ultrasound guidance, small probes are placed strategically around the tumor.
Delivery of Pulses: Electrical pulses are sent through the probes, destroying only the cancer cells.
Tissue Preservation: Surrounding structures remain intact, reducing the risk of side effects.
Short Recovery: The procedure is done under general anesthesia, and most patients return home the same day.

Benefits of NanoKnife for Prostate Cancer

Minimally Invasive: No large incisions; electrodes are inserted via thin needles.
Fast Recovery: Most patients resume normal activities within a week.
Preserved Quality of Life: Low risk of erectile dysfunction and urinary incontinence.
Repeatable: Can be used again if needed and does not eliminate other treatment options.

Post-Procedure and Recovery

After the procedure:

Most patients experience only mild discomfort.
A PSA test at 3 months helps evaluate the effectiveness of the treatment.
Follow-up includes PSA tests at 3, 6, and 12 months, and a repeat MRI at 12 months to monitor for any signs of recurrence.
If necessary, additional NanoKnife sessions or other treatments can be planned.

Long-Term Monitoring and Care

Ongoing care is essential for continued success. At UPNT:

Why Choose UPNT for NanoKnife Treatment?

Experienced Specialists: Our physicians are pioneers in focal prostate therapies, with years of hands-on expertise in IRE and NanoKnife treatments.
State-of-the-Art Technology: We use the latest-generation NanoKnife system for superior accuracy and safety.
Personalized Care Plans: Every patient receives a custom treatment plan based on tumor location, stage, and personal health goals.
Comprehensive Support: From consultation to recovery, our team is committed to guiding you every step of the way.

Frequently Asked Questions (FAQs)

How long does the NanoKnife procedure take?

The procedure usually takes 60-90 minutes, depending on the tumor’s size and location.

Is NanoKnife covered by insurance?

Most insurance providers cover NanoKnife for prostate cancer, but it’s best to confirm with your insurance company.

How soon will I know if it worked?

A PSA test at 3 months post-procedure provides initial insight. Ongoing tests track long-term success.

Will it affect sexual function?

NanoKnife’s precision helps preserve the nerves responsible for erections, with many patients maintaining erectile function.

Is the procedure painful?

It is done under general anesthesia, so there’s no pain during the procedure. Mild discomfort afterward is typically managed with medication.

How often will I need follow-up scans?

Follow-up includes PSA tests at 3, 6, and 12 months, and a repeat MRI at 12 months to ensure continued cancer control.

Could the cancer come back after NanoKnife treatment?

Maybe. While NanoKnife effectively targets and destroys cancerous tissue, there is a possibility of recurrence. Studies have shown that in-field recurrence rates (within the treated area) range from approximately 2.7% to 9.8%, while out-of-field recurrence rates (outside the treated area) can be around 12.5%. Regular follow-up with PSA tests and imaging is crucial to monitor for any signs of recurrence and to manage them promptly. PMC PMC

Take the Next Step with UPNT

If you’ve been diagnosed with localized prostate cancer and want a minimally invasive, function-preserving treatment, NanoKnife at UPNT may be the ideal solution. Contact us today to schedule a consultation and learn more about your personalized options.